RAS GTPase inhibitor 1

发表于由

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RAS GTPase inhibitor 1 

RAS GTPase inhibitor 1 (example 51) 是RAS GTPase 的抑制剂，具有抗肿瘤活性，信息来自专利WO2018212774A1。RAS GTPase inhibitor 1 (example 51) 对至少一个核苷酸交换的EC50 值为< 1 μM，对H727 细胞的IC50 值为< 1 μM。

RAS GTPase inhibitor 1

RAS GTPase inhibitor 1 Chemical Structure

CAS No. : 2252242-32-1

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生物活性

RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells[1].

IC50 & Target

IC50: < 1 μM (H727 cells)[1].
EC50: < 1 μM (nucleotide exchange)[1].
分子量

565.99

Formula

C27H28ClF4N5O2
CAS 号

2252242-32-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. WATERSON, Alex G, et al. QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING. Patent. WO2018212774A1.

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