Antitumor agent-19

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-19 

Antitumor agent-19 是一种靶向肿瘤相关巨噬细胞 (TAMs) 的抗肿瘤药，可用作有效的 TAMs 调节剂。Antitumor agent-19 在 RAW 264.7 细胞和 BMDM 细胞中的 EC50 值分别为 17.18 µM 和 18.87 µM。

Antitumor agent-19

Antitumor agent-19 Chemical Structure

CAS No. : 2379727-90-7

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生物活性

Antitumor agent-19 is an antitomor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator. The EC50 values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively[1].

IC50 & Target

tumor-associated macrophages (TAMs)[1]
体外研究
(In Vitro)

Antitumor agent-19 (Compound 23a; 10-50 µM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM, or 50 µM
Incubation Time: 1 hour
Result: Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.

体内研究
(In Vivo)

Antitumor agent-19 (Compound 23a; 5 mg/kg; intraperitoneal injection; every other day; for 30 days; C57BL/6 female mice) is capable of remarkably inhibiting tumor growth of the LLC mouse model. Moreover, the synergy of Antitumor agent-19 with anti-PD-1 antibody has more superior antineoplastic effects than the exclusive use of either in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; every other day; for 30 days
Result: Remarkably inhibited tumor growth of the LLC mouse model.

分子量

487.90

Formula

C24H21ClF3N5O
CAS 号

2379727-90-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Pei H, et al. iscovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Sep 28;183:111741.

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