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FM26
FM26 (化合物 25) 是一种有效的变构的维甲酸受体相关孤儿受体 γt (RORγt) 反向激动剂，IC50 为 264 nM。FM26 具有独特的异恶唑化学型，可有效减少 EL4 细胞中 IL-17a mRNA 的生成。
FM26 Chemical Structure
CAS No. : 2407981-35-3
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1]. |
IC50 & Target |
IC50: 264 nM (RORγt)[1] |
|---|---|
| 体外研究 (In Vitro) |
FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
461.82 |
| Formula |
C22H15ClF3N3O3 |
| CAS 号 |
2407981-35-3 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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