DC4, an ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4 can be used for the targeted treatment of cancer^[1].

DC4 can be conjugated to the humanized monoclonal antibody huB4 and huC242 by a linker SPP, SPDB, and SMCC to form huB4-SPP-DC44, huC242-SPDB-DC4, huC242-SPP-DC4, and huC242-SMCC-DC4^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

718.12

C₃₄H₂₉ClN₅O₇PS

615538-48-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.