DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC₅₀ of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application^[1].

IC50: 0.60 μM (rat TrxR1)^[1]

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC₅₀s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

458.50

C₂₅H₂₈F₂N₂O₄

2375846-41-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jovanović M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580.