上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
S-methyl DM1
S-methyl DM1 是一种美登素 (Maytansine) 的硫代甲基衍生物。S-methyl DM1 以 Kd 为 0.93 μM 结合微管蛋白并抑制微管聚合。S-methyl DM1 可以有效抑制微管动态不稳定性,并具有抗癌作用。
S-methyl DM1 Chemical Structure
CAS No. : 912569-84-7
规格 | 是否有货 | ||
---|---|---|---|
500 μg | 询价 | ||
1 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2]. |
|
---|---|---|
IC50 & Target |
|
|
体外研究 (In Vitro) |
S-methyl DM1 is the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
|
分子量 |
752.31 |
|
Formula |
C36H50ClN3O10S |
|
CAS 号 |
912569-84-7 |
|
运输条件 |
Room temperature in continental US; may vary elsewhere. |
|
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
|
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务