CEM114

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CEM114 

CEM114 是一种有效的化学表观遗传修饰剂 (CEM)，可通过 CRISPR-Cas9 系统募集内源性染色质机制。

CEM114

CEM114 Chemical Structure

CAS No. : 2279062-54-1

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生物活性

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

体外研究
(In Vitro)

CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK 293T cells
Concentration: 200 nM
Incubation Time: 48 hours
Result: Significantly activated the GFP signal.

分子量

1612.98

Formula

C84H122FN9O19S
CAS 号

2279062-54-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

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