上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Mcl1-IN-9
Mcl1-IN-9 是一种有效的髓细胞白血病基因 1 (Mcl-1) 抑制剂,在重组的 BCR-ABL+ B-ALL 细胞中的 IC50 值为 446 nM,Ki 值为 0.03 nM。
Mcl1-IN-9 Chemical Structure
CAS No. : 1810769-31-3
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生物活性 |
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
639.18 |
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Formula |
C37H39ClN4O4 |
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CAS 号 |
1810769-31-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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