CYP17-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CYP17-IN-1 

CYP17-IN-1 (compound 9c) 是一种有效的，具有口服活性的 CYP17 的抑制剂，对大鼠和人 CYP17 的 IC50 值为 15.8 和 20.1 nM。

CYP17-IN-1

CYP17-IN-1 Chemical Structure

CAS No. : 2093317-51-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

IC50 & Target

IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]
体外研究
(In Vitro)

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

312.40

Formula

C18H17FN2S
CAS 号

2093317-51-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务