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Simvastatin hydroxy acid sodium (Synonyms: Tenivastatin sodium; Simvastatin Impurity A sodium)
Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) 是辛伐他汀 (HY-17502) 活性水解代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂， Ki 值为 0.2 nM。
Simvastatin hydroxy acid sodium Chemical Structure
CAS No. : 101314-97-0
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) is an active hydrolytic metabolite of Simvastatin (HY-17502)[1]. Simvastatin shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[2]. |
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| 体外研究 (In Vitro) |
Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1].Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
458.56 |
| Formula |
C25H39NaO6 |
| CAS 号 |
101314-97-0 |
| 中文名称 |
辛伐他汀羟基酸 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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