C-11

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

C-11 

C-11 是一种微管蛋白抑制剂，也是一种 ADC 细胞毒素，对癌细胞具有细胞毒性。

C-11

C-11 Chemical Structure

CAS No. : 2007965-97-9

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生物活性

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

C-11 exhibits cytotoxicity for N87 cells and MDA-MB-361-DYT2 cells with IC50s of 1.11 nM and 0.9 nM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

742.97

Formula

C38H58N6O7S
CAS 号

2007965-97-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

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