Gypenoside LI 是一种绞股蓝赶单体,具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。
Gypenoside LI Chemical Structure
CAS No. : 94987-10-7
规格
价格
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数量
5 mg
¥4500
In-stock
10 mg
询价
50 mg
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Gypenoside LI 相关产品
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生物活性
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration[1][2].
体外研究 (In Vitro)
Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1]. Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1]. Gypenoside LI could obviously suppress the expression of CDK1 protein rather than CDK2 and CDK4 proteins[1]. Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2]. Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2]. Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
A549 cells.
Concentration:
0-80 μM.
Incubation Time:
24 h.
Result:
Displayed the strongest activity with the IC50 values of 21.36 ± 0.78 μM.
分子量
801.01
Formula
C42H72O14
CAS 号
94987-10-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Shao-Fang Xing, et al. The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells. J Ethnopharmacol. 2018 Jun 12;219:161-172.
[2]. Ma-Li Zu, et al. Monomer gypenoside LI from Gynostemma pentaphyllum inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells. J Biochem Mol Toxicol. 2020 May;34(5):e22460.