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Casein Kinase inhibitor A86 纯度: 98.47%
Casein Kinase inhibitor A86 是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂。Casein Kinase inhibitor A86 还抑制 CDK7 (TFIIH) 和 CDK9 (P-TEFb)。Casein Kinase inhibitor A86 可诱导白血病细胞凋亡 (apoptosis),并具有有效的抗白血病活性。
Casein Kinase inhibitor A86 Chemical Structure
CAS No. : 2079069-01-3
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥4000 | In-stock | |
10 mg | ¥6800 | In-stock | |
25 mg | ¥13500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Casein Kinase inhibitor A86 相关产品
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生物活性 |
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Casein Kinase inhibitor A86 is highly effective in inducing leukemia cell apoptosis at 160 nM or lower, mostly in correlation to their capacity to stabilize p53[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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体内研究 (In Vivo) |
Pharmacokinetic studies of the inhibitor Casein Kinase inhibitor A86 at 20 mg/kg reveal rapid oral absorption with a Tmax of 0.2-0.5 hr, Cmax of 1115 ng/mL, T1/2 of 4.3 hr, and area under the curve (AUC) values of 2606 (ng*hr/mL)[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
344.43 |
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Formula |
C18H25FN6 |
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CAS 号 |
2079069-01-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 12.5 mg/mL (36.29 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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