QTX125

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

QTX125 

QTX125 是一种有效且高度选择性的 HDAC6 抑制剂。与其他 HDAC 相比，QTX125 对 HDAC6 具有出色的选择性。QTX125 具有抗肿瘤作用。

QTX125

QTX125 Chemical Structure

CAS No. : 1279698-31-5

规格 价格 是否有货
5 mg ￥3800 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期
25 mg ￥11500 询问价格 & 货期
50 mg ￥18000 询问价格 & 货期

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生物活性

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50 & Target[1]

HDAC6

 

体外研究
(In Vitro)

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours, 48 hours
Result: Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours
Result: Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.

体内研究
(In Vivo)

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing REC-1 or MINO cells[1]
Dosage: 60 mg/kg
Administration: Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result: Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.

分子量

417.41

Formula

C23H19N3O5
CAS 号

1279698-31-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Montserrat Pérez-Salvia, et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. 2018 Nov;103(11):e537-e540.

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