Epitalon(Synonyms: Epithalon; Epithalamin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Epitalon (Synonyms: Epithalon; Epithalamin)

Epitalon 是一种抗衰老剂和端粒酶激活剂。Epitalon 对小鼠自发性肿瘤的发展具有抑制作用,具有 geroprotective 作用,通过鼻内给药可增加神经元活性。Epitalon 可用于癌症,衰老和色素性视网膜炎。

Epitalon(Synonyms: Epithalon;  Epithalamin)

Epitalon Chemical Structure

CAS No. : 307297-39-8

规格 价格 是否有货
1 mg ¥650 询问价格 & 货期
5 mg ¥1950 询问价格 & 货期
10 mg ¥3500 询问价格 & 货期
25 mg ¥7500 询问价格 & 货期

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Epitalon 的其他形式现货产品:

Epitalon TFA

生物活性

Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa[1].

体外研究
(In Vitro)

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

390.35

Formula

C14H22N4O9

CAS 号

307297-39-8

Sequence Shortening

AEDG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

    [2]. Vanhee C, et al. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Test Anal. 2015 Mar;7(3):259-64.

    [3]. Khavinson VKh, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.

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