NSAH

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NSAH  纯度: 98.62%

NSAH 是可逆的、竞争性的非核苷类的核苷酸还原酶 (RR)的抑制剂，其 cell-free 和 cell-bases 的 IC50 值分别为 32 μM 和 ~250 nM。

NSAH

NSAH Chemical Structure

CAS No. : 1099592-35-4

规格 价格 是否有货 数量
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
25 mg ￥2800 In-stock
50 mg ￥4500 In-stock
100 mg ￥7200 In-stock
200 mg   询价  
500 mg   询价  

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NSAH 相关产品

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生物活性

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

体外研究
(In Vitro)

NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells[1].
NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines[1].
NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-231, HCT116 and Panc1 cancer cell lines.
Concentration: 0-10 μM.
Incubation Time: 2, 6, 24, or 72 h.
Result: Resulted in IC50 values ranging from 220 to 500 nM.

分子量

306.32

Formula

C18H14N2O3
CAS 号

1099592-35-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2646 mL 16.3228 mL 32.6456 mL
5 mM 0.6529 mL 3.2646 mL 6.5291 mL
10 mM 0.3265 mL 1.6323 mL 3.2646 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246.

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