RI(dl)-2 TFA

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RI(dl)-2 TFA  纯度: ≥98.0%

RI(dl)-2 TFA 是一种有效的选择性 RAD51 介导的 D 环形成 (RAD51-mediated D-loop formation) 抑制剂，IC50 为 11.1 μM。RI(dl)-2 TFA 不会影响 RAD51 与 ssDNA 的结合，并会抑制人细胞中的同源重组 (HR) 活性 (IC50 为 3.0 μM)。

RI(dl)-2 TFA

RI(dl)-2 TFA Chemical Structure

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5 mg ￥5500 In-stock
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生物活性

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].

IC50 & Target

IC50: 11.1 μM (RAD51-mediated D-loop formation)[1]
体外研究
(In Vitro)

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].
RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

435.59

Formula

C21H18F3N3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25.

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