Guanylin(human)

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Guanylin(human) 

Guanylin(human),一种 15 个氨基酸的肽,是一种内源性肠鸟苷酸环化酶 (intestinal guanylate cyclase) 激活剂。Guanylin(human) 主要存在于胃肠道中,其通过 cGMP 依赖性机制调节肠和肾上皮中电解质水的运输。

Guanylin(human)

Guanylin(human) Chemical Structure

CAS No. : 183200-12-6

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Guanylin(human) 的其他形式现货产品:

Guanylin(human) TFA

生物活性

Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism[1][2].

分子量

1458.66

Formula

C58H87N15O21S4

CAS 号

183200-12-6

Sequence Shortening

PGTCEICAYAACTGC (Disulfide bridge:Cys4-Cys12;Cys7-Cys15)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. M G Currie, et al. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):947-51.

    [2]. J Bełtowski. Guanylin and related peptides. J Physiol Pharmacol. 2001 Sep;52(3):351-75.

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