R18(Synonyms: PHCVPRDLSWLDLEANMCLP) | 赛默飞Alfa aesar官网

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R18 (Synonyms: PHCVPRDLSWLDLEANMCLP)

R18 是 14-3-3 的肽拮抗剂，其 K_D 值为 70-90 nM。R18 可有效阻断 14-3-3 与其配体 Raf-1激酶的结合，可有效地消除 14-3-3 对磷酸酶诱导的 Raf-1 失活的保护作用。

R18 Chemical Structure

CAS No. : 211364-78-2

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R18 的其他形式现货产品:

R18 TFA

生物活性	R18 is a peptide antagonists of 14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1^[1].
分子量	2309.69
Formula	C₁₀₁H₁₅₇N₂₇O₂₉S₃
CAS 号	211364-78-2
Sequence	Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening	PHCVPRDLSWLDLEANMCLP
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.

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