Echitamine chloride(Synonyms: 氯化埃奇胺)

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Echitamine chloride (Synonyms: 氯化埃奇胺) 纯度: ≥98.0%

Echitamine chloride 是存在于 Alstonia 中的主要单萜吲哚生物碱，具有有效的抗肿瘤活性。Echitamine chloride 会诱导 DNA 片段化和细胞凋亡 (apoptosis)。Echitamine chloride 抑制胰腺脂肪酶 (pancreatic lipase)，IC50 为 10.92 µM。

Echitamine chloride(Synonyms: 氯化埃奇胺)

Echitamine chloride Chemical Structure

CAS No. : 6878-36-0

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5 mg ￥12000 In-stock
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生物活性

Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 µM[1][2].

IC50 & Target

IC50: 10.92 µM (Pancreatic lipase)[2]
分子量

420.93

Formula

C22H29ClN2O4
CAS 号

6878-36-0
中文名称

氯化埃奇胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57(9):1213-9.

    [2]. Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5.

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