THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

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THP-PEG4-Pyrrolidine(N-Boc)-CH2OH  纯度: ≥95.0%

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 是基于 PEG 结构的 PROTAC linker, 可以用来制备 PROTAC K-Ras Degrader-1 (HY-129523)。

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH Chemical Structure

CAS No. : 2378261-80-2

规格 价格 是否有货 数量
100 mg ￥3500 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

477.59

Formula

C23H43NO9
CAS 号

2378261-80-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

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