DYRKs-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DYRKs-IN-1 

DYRKs-IN-1 是一种有效的 DYRKs (双特异性酪氨酸磷酸化调节激酶) 抑制剂，对 DYRK1A 和 DYRK1B 的 IC50 分别为 5 nM 和 8 nM。DYRKs-IN-1 有抗肿瘤活性。

DYRKs-IN-1

DYRKs-IN-1 Chemical Structure

CAS No. : 1387090-01-8

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DYRKs-IN-1 的其他形式现货产品:

DYRKs-IN-1 hydrochloride

生物活性

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity[1][2].

IC50 & Target[1]

DYRK1A

5 nM (IC50)

DYRK1B

8 nM (IC50)

体外研究
(In Vitro)

DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1].
DYRKs-IN-1 (Example 183) is a potent DYRKs inhibitor[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

588.06

Formula

C30H30ClN7O4
CAS 号

1387090-01-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.

    [2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.

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