G3-C12 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

G3-C12

G3-C12 是 galectin-3 结合肽，K_d 值为 88 nM，具有抗肿瘤活性。

G3-C12 Chemical Structure

CAS No. : 848301-94-0

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G3-C12 的其他形式现货产品:

G3-C12 TFA

生物活性

G3-C12 is a galectin-3 binding peptide, with K_d of 88 nM, and shows anticancer activity.

IC₅₀ & Target

Kd: 88 nM (Galectin-3)^[1]

体外研究
(In Vitro)

G3-C12 is a galectin-3 binding peptide, with high affinity (K_d) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1758.98

Formula

C₇₄H₁₁₅N₂₃O₂₃S₂

CAS 号

848301-94-0

Sequence

Ala-Asn-Thr-Pro-Cys-Gly-Pro-Tyr-Thr-His-Asp-Cys-Pro-Val-Lys-Arg

Sequence Shortening

ANTPCGPYTHDCPVKR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.

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