Axitinib-d3(Synonyms: AG-013736-d3)

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Axitinib-d3 (Synonyms: AG-013736-d3) 纯度: 97.42%

Axitinib-d3 是氘标记的 Axitinib。Axitinib 是多靶点的酪氨酸激酶抑制剂,抑制 VEGFR1VEGFR2VEGFR3 PDGFRβIC50 值分别为4,20,4,2 nM。

Axitinib-d3(Synonyms: AG-013736-d3)

Axitinib-d3 Chemical Structure

CAS No. : 1126623-89-9

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1 mg ¥11000 In-stock
5 mg ¥52000 In-stock
10 mg ¥98000 In-stock
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生物活性

Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

分子量

389.49

Formula

C22H15D3N4OS

CAS 号

1126623-89-9

中文名称

阿昔替尼 d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Fenton BM, et al. The addition of AG-013736 to rractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15;67(20):9921-8

    [2]. Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83

    [3]. Allen E, et al. Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 2016 May 10;15(6):1144-60.

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