S100P-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S100P-IN-1 

S100P-IN-1 (Compound 4) 是一种 S100P 抑制剂，其 IC50值为 22.7 nM。S100P-IN-1 对胰腺癌 (pancreatic) 细胞具有抗转移作用。

S100P-IN-1

S100P-IN-1 Chemical Structure

CAS No. : 690991-06-1

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生物活性

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells[1].

IC50 & Target

IC50: 22.7 nM (S100P)[1]
体外研究
(In Vitro)

S100P-IN-1 (Compound 4) blocks S100P binding to RAGE in a dose dependent manner[1].
S100P-IN-1 (10 µM, 24 h) shows S100P-specific inhibitory effect on cell invasion, without obvious cytotoxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay[1]

Cell Line: Human pancreatic cancer cell lines PanC-1 (ATCC- CRL-1469), and BxPC-3 (ATCC-CRL-1687)
Concentration: 10 µM
Incubation Time: 48 h
Result: Significantly inhibited invasion to the lower chamber in BxPC-3 cells, but didn’t inhibit invasion of PanC-1 (lack S100P expression) cells.

Cell Viability Assay[1]

Cell Line: BxPC-3 and Panc-1 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Showed no significant effect on cell metabolic activity and cytotoxicity in either cell line.

分子量

440.40

Formula

C25H16N2O6
CAS 号

690991-06-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ramatoulie Camara, et al. Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells. Eur J Med Chem. 2020 Oct 1;203:112621.

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