Margetuximab

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Margetuximab 

Margetuximab 是一种嵌合抗 HER2 单克隆抗体，具有优化的 Fc 结构域，EC50 为 39.33 ng/mL。Margetuximab 可用于抗癌研究。

Margetuximab

Margetuximab Chemical Structure

CAS No. : 1350624-75-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Margetuximab is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching anticancer[1].

IC50 & Target

EC50: 39.33 ng/mL (HER2)[1]
体外研究
(In Vitro)

Margetuximab enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: JIMT-1, MCF-7, ZR-75-1, SKBR-3, HT-29, SW750 and N87[1]
Concentration: 0.001-1000 ng/mL
Incubation Time: 6 days
Result: Enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.

体内研究
(In Vivo)

Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 – 37 in mice model[1].
Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release[1].
Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile[1].
Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys[1].

Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL) 1.62 ± 0.10 1.70 ± 0.14
AUC0-¥ (mg·hour/mL) 294.1 ± 53.2 314.2 ± 31.3
T1/2β (days) 9.3 ± 1.8 9.7 ± 1.1
Clearance (mL/hour) 0.43 ± 0.07 0.40 ± 0.04
VSS (mL) 132 ± 2 127 ± 8

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号

1350624-75-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nordstrom JL, et al. Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties. Breast Cancer Res. 2011;13(6):R123. doi:10.1186/bcr3069

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务