Topo I-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Topo I-IN-1 

Topo I-IN-1 (Compound 14d) 是一种具有抗肿瘤活性和DNA嵌入能力的 Topo I抑制剂。Topo I-IN-1 诱导细胞凋亡 (apoptosis)。

Topo I-IN-1

Topo I-IN-1 Chemical Structure

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生物活性

Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis[1].

IC50 & Target

Topoisomerase I

 

体外研究
(In Vitro)

Topo I-IN-1 (Compound 14d) (0-50 µM, 48 h) shows antiproliferative activity against human cancer cells and has low toxicity toward normal rat kidney epithelial cells[1].
Topo I-IN-1 (0-4 µM, 48 h) shows a dose-dependent apoptotic effect, induces ROS generation, and inhibits cell migration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549, HCT116, MCF7, SK-MEL-28, and NRK (normal rat kidney epithelial cells)
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed in vitro cytotoxicity with IC50 values of 2.33 ± 1.52, 2.85 ± 0.83, 26.23 ± 2.48, 3.86 ± 0.33, and 29.99 ± 0.95 µM against A549, HCT116, MCF7, SK-MEL-28, and NRK cells, respectively.

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 2, 2.33 and 4 μM
Incubation Time: 48 h
Result: Resulted in the morphological changes typical to apoptosis.

分子量

408.25

Formula

C20H14BrN3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Manasa Kadagathur, et al. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors. Bioorg Chem. 2022 May;122:105706.

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