SIRT1-IN-3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SIRT1-IN-3 

SIRT1-IN-3 (compound 3j) 是一种有效且选择性的 SIRT1 抑制剂，其IC50 为 4.2 μM。

SIRT1-IN-3

SIRT1-IN-3 Chemical Structure

CAS No. : 2470969-91-4

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生物活性

SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1].

IC50 & Target

SIRT1

4.2 μM (IC50)

SIRT2

38 μM (IC50)

体外研究
(In Vitro)

SIRT1-IN-3 (compound 3j) (0-100 μM, 48 h) inhibits the proliferation of human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, and shows low cytotoxic on 293T and HUVEC[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC)[1]
Concentration: 0, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 h
Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, with IC50 values of 47, 41, 66, 93, 52, and 64 μM, respectively. And showed low cytotoxic on 293T and HUVEC, with an IC50 values of 49 and 45 μM, respectively.

分子量

295.18

Formula

C13H15BrN2O
CAS 号

2470969-91-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561.

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