Selatinib

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Selatinib 

Selatinib 是一种可逆且具有口服活性的双重 EGFR 和 ErbB2 抑制剂，IC50 分别为 13 nM 和 22.5 nM。Selatinib 具有抗癌作用。

Selatinib

Selatinib Chemical Structure

CAS No. : 1275595-86-2

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生物活性

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].

IC50 & Target[1]

EGFR

13 nM (IC50)

ErbB2

22.5 nM (IC50)

分子量

565.06

Formula

C29H26ClFN4O3S
CAS 号

1275595-86-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meng-Na Wang, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020 Dec;38(6):1826-1835.

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