FAK-IN-4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FAK-IN-4 

FAK-IN-4 (Compound 7d) 是具有抗癌活性的潜在 FAK 抑制剂。FAK-IN-4 诱导细胞凋亡 (apoptosis)。

FAK-IN-4

FAK-IN-4 Chemical Structure

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生物活性

FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis[1].

体外研究
(In Vitro)

FAK-IN-4 (Compound 7d) (0-200 μM, 72 h) shows antiproliferative activity against triple-negative breast cancer (TNBC) cells[1].
FAK-IN-4 (0-20 μM, 24 h) inhibits cell invasion and migration of MDA-MB-231 cells[1].
FAK-IN-4 (0-20 μM, 72 h) causes dose-dependent Y925 dephosphorylation of FAK, and induces apoptosis in MDA-MB-231 cells[1].
FAK-IN-4 inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A
Concentration: 0.78, 1.56, 3.13, 5, 6.25, 100, 12.5, 25, 50, 100 and 200 μM
Incubation Time: 72 h
Result: Inhibited the growth of TNBC cells with IC50 values of 8.37, 12.09, 9.07 and 40.63 μM against MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A cells.

Cell Invasion Assay[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: Significantly inhibited the invasion of MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 72 h
Result: Caused an obvious dose-dependent Y925 dephosphorylation of FAK.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 72 h
Result: Increased the percentage of apoptotic MDA-MB-231 cells ranging from 13.10% to 41.59% in a dose-dependent manner.

分子量

334.41

Formula

C20H22N4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fei Yang, et al. Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer. Bioorg Med Chem. 2022 Jul 15;66:116809.

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