FAK-IN-5

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FAK-IN-5 

FAK-IN-5 (Compound 8l) 是一种 FAK signaling 抑制剂。FAK-IN-5 诱导细胞凋亡(apoptosis) 和自噬 (autophagy)。

FAK-IN-5

FAK-IN-5 Chemical Structure

CAS No. : 2408317-70-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy[1].

体外研究
(In Vitro)

FAK-IN-5 (Compound 8l) (0-50 µM, 72 h) shows antiproliferative activity against cancer cells[1].
FAK-IN-5 (Compound 8l) causes cell detachment[1].
FAK-IN-5 (Compound 8l) (0-25 µM, 24 h) induces autophagy and apoptosis in HCT-116 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: K562, CEM, G361, MCF-7 and HCT-116
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50 values of 6.3, 7.9, 6.3, 5.5 and 5.3 µM against K562, CEM, G361, MCF-7 and HCT-116 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 1.25, 2.5, 5, 7, 10, 11, 17 and 25 µM
Incubation Time: 1, 3, 5, 7 and 24 h
Result: Caused the dephosphorylation of FAK, p130Cas and paxillin in a dose-dependent manner. The dephosphorylation of FAK at Y397 was observed at a much earlier time point. Detected the fragments of activated caspase-7 as well as the dose-dependent cleavage of poly (ADP-ribose) polymerase (PARP).

分子量

576.01

Formula

C29H29ClF3N3O4
CAS 号

2408317-70-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jorda R, et al. Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells. Eur J Med Chem. 2020 Feb 15;188:112036.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务