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Nogalamycin
Nogalamycin 是一种羟硝氨糖环素。Nogalamycin 是抗革兰氏阳性细菌的有效抗生素,对某些肿瘤细胞也具有细胞毒性。Nogalamycin 由 Streptomyces nogalater var. Nogalater 菌株产生。Nogalamycin 与 DNA 模板结合后选择性抑制 RNA 合成。可用于抗癌研究。
Nogalamycin Chemical Structure
CAS No. : 1404-15-5
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生物活性 |
Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2]. |
IC50 & Target |
RNA Synthesis[2] |
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体外研究 (In Vitro) |
Nogalamycin (0-10 μg/ml; 2 hours) exhibits lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay
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体内研究 (In Vivo) |
Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
787.80 |
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Formula |
C39H49NO16 |
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CAS 号 |
1404-15-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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