ASK1-IN-3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ASK1-IN-3 

ASK1-IN-3 是一种有效且具有选择性的 ASK1 激酶抑制剂，IC50 为 33.8 nM，同时也抑制多种细胞周期调节激酶。ASK1-IN-3 具有较强的 HepG2 癌细胞凋亡 (apoptosis) 诱导活性与有效的细胞周期阻滞活性。

ASK1-IN-3

ASK1-IN-3 Chemical Structure

CAS No. : 2426705-19-1

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生物活性

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

IC50 & Target

IC50: 33.8 nM (ASK1)[1]
体外研究
(In Vitro)

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line: HepG2[1]
Concentration: 10, 20 and 50 μM
Incubation Time: 48 hours
Result: Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line: HepG2[1]
Concentration: 1, 2, 4, 8, and 16 μM
Incubation Time: 24 hours
Result: Significantly arrested cycle progression at G1 phase.

分子量

378.39

Formula

C18H18N8O2
CAS 号

2426705-19-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277.

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