WAY-170523

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

WAY-170523 

WAY-170523 是一种强效的选择性 MMP-13 (基质金属蛋白酶-13) 抑制剂，其IC50 为 17 nM。WAY-170523 可直接减弱 ERK1/2 磷酸化。WAY-170523 可抑制 PC-3 细胞的侵袭，可用于前列腺癌的研究。

WAY-170523

WAY-170523 Chemical Structure

CAS No. : 307002-73-9

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生物活性

WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].

IC50 & Target

MMP13

17 nM (IC50)

MMP-1

10 μM (IC50)

MMP-9

945 nM (IC50)

体外研究
(In Vitro)

WAY-170523 has an IC50 of 17 nM for MMP-13 and shows > 5800-, 56-, and > 500-fold selectivity against MMP-I, MMP-9, and TACE, respectively.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

613.68

Formula

C33H31N3O7S
CAS 号

307002-73-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.

    [2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.

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