Tyrphostin 25(Synonyms: AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875)

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Tyrphostin 25 (Synonyms: AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875)

Tyrphostin 25 (AG82) 是一种 EGFR 酪氨酸激酶的特异性抑制剂。Tyrphostin 25 也是一种 GPR35 激动剂,IC50 值为 0.94 µM,EC50 值为 5.3 µM。

Tyrphostin 25(Synonyms: AG82;  Tyrphostin A 25;  Tyrphostin AG 82;  RG-50875)

Tyrphostin 25 Chemical Structure

CAS No. : 118409-58-8

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生物活性

Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC50 of 0.94 µM and an EC50 of 5.3 µM[1][2].

IC50 & Target

EGFR tyrosine kinase[1]
IC50: 0.94 µM (GPR35)[2]
EC50: 5.3 µM (GPR35)[2]

分子量

202.17

Formula

C10H6N2O3

CAS 号

118409-58-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127(3):859-66.

    [2]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62.

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