Tubulin inhibitor 22

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin inhibitor 22 

Tubulin inhibitor 22 (compound 4c) 是一种有效的 tubulin 抑制剂，具有抗血管生成和抗癌特性。Tubulin inhibitor 22 在 G2/M 期阻止 MGC-803 细胞周期。Tubulin inhibitor 22 剂量依赖性地通过线粒体功能障碍引起 Caspase 诱导的 MGC-803 细胞凋亡 (apoptosis)。

Tubulin inhibitor 22

Tubulin inhibitor 22 Chemical Structure

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生物活性

Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction[1].

分子量

434.26

Formula

C20H17BrFNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun M, et al. Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022;37(1):339-354.

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