1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one

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1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one 

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one （compound 6） 显示出抗增殖活性，26-L5 和 HT-1080 细胞的 ED50 值分别为 57.7 和 78.8 µM。1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one 抑制 B16 黑色素瘤4A5 细胞中的黑色素形成。1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one 具有研究皮肤性疾病的潜能。

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one Chemical Structure

CAS No. : 332371-82-1

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生物活性

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].

体外研究
(In Vitro)

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 2) (1-10 µM) inhibits melanogenesis in B16 melanoma 4A5 cells with an IC50 of 1.99 µM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

294.34

Formula

C19H18O3
CAS 号

332371-82-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93.

    [2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.

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