PAK1-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAK1-IN-1 

PAK1-IN-1 是一种有效的选择性 PAK1 抑制剂，IC50 为 9.8 nM。PAK1-IN-1以剂量依赖性方式抑制 PAK1 相关肿瘤细胞的迁移和侵袭。

PAK1-IN-1

PAK1-IN-1 Chemical Structure

CAS No. : 2485732-30-5

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生物活性

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

IC50 & Target[1]

PAK1

9.8 nM (IC50)

PAK4

>10 μM (IC50)

体外研究
(In Vitro)

PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT-116 cells
Concentration: 1 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 20 µM
Incubation Time: 1, 24 h
Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.

分子量

469.92

Formula

C26H20ClN5O2
CAS 号

2485732-30-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.

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