VEGFR-2-IN-18

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VEGFR-2-IN-18 

VEGFR-2-IN-18 (Compound 15d) 是一种有效的 VEGFR-2 抑制剂，IC50 值为 60 nM。VEGFR-2-IN-18 诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。

VEGFR-2-IN-18

VEGFR-2-IN-18 Chemical Structure

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生物活性

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities[1].

IC50 & Target

VEGFR2

60 nM (IC50)

体外研究
(In Vitro)

VEGFR-2-IN-18 (Compound 15d) shows antiproliferative activities with IC50 values of 24.10 ± 2.12, 40.90 ± 3.46, 33.40 ± 2.92 and 221.25 ± 2.55 µM against HepG2, PC3, MCF-7 and WI-38 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

376.80

Formula

C20H13ClN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdallah AE, et al. Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):573-591.

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