VEGFR-2-IN-15

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VEGFR-2-IN-15 

VEGFR-2-IN-15 (Compound 14b) 是一种有效的 VEGFR-2 抑制剂。VEGFR-2-IN-15 抑制 HepG2 细胞在 Pre-G1 期的生长，诱导细胞凋亡 (apoptosis)。

VEGFR-2-IN-15

VEGFR-2-IN-15 Chemical Structure

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生物活性

VEGFR-2-IN-15 (Compound 14b) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-15 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis[1].

IC50 & Target

VEGFR2

 

体外研究
(In Vitro)

VEGFR-2-IN-15 (Compound 14b) shows cytotoxic activities with IC50 values of 4.754 ± 0.21 µM and 4.61 ± 0.34 µM against MCF-7 and HepG2 cells, respectively[1].
VEGFR-2-IN-15 shows the highest activities with VEGFR-2 protein concentrations of 705.7 pg/ml[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

467.92

Formula

C23H18ClN3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Elkady H, et al. New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37(1):397-410.

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