2,4-PDCA

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2,4-PDCA 

2,4-PDCA (2,4 pyridine dicarboxylic acid) 是一种广谱的 2OG 氧合酶 (2OG oxygenase) 抑制剂，包括含 JmjC 结构域的组蛋白去甲基化酶家族 (JHDMs)。2,4-PDCA 是生物塑料领域的目标化学品。

2,4-PDCA

2,4-PDCA Chemical Structure

CAS No. : 499-80-9

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生物活性

2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].

分子量

167.12

Formula

C7H5NO4
CAS 号

499-80-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

    [2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638.

    [3]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

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