CDK2-IN-9

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK2-IN-9 

CDK2-IN-9 是一种有效的 CDK2 抑制剂，IC50 为 0.63 µM。CDK2-IN-9 显示出抗增殖活性。CDK2-IN-9 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S 和 G2/M 期。CDK2-IN-9 具有研究黑色素瘤的潜力。

CDK2-IN-9

CDK2-IN-9 Chemical Structure

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生物活性

CDK2-IN-9 is a potent CDK2 inhibitor with an IC50 of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma[1].

IC50 & Target[1]

CDK2

0.63 μM (IC50)

体外研究
(In Vitro)

CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC50s of 3.03, 8.62, 62.52 µM for MDA-MB-435, SNB-75, WI-38 cells, respectively[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration: 3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration:
Incubation Time: 24 h
Result: Induced cell cycle arrest at S phase and G2/M.

分子量

441.89

Formula

C21H16ClN3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mohammed ER, et al. Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma. J Enzyme Inhib Med Chem. 2022 Dec;37(1):686-700.

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