FGFR4-IN-9 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FGFR4-IN-9

FGFR4-IN-9 (Compound 6O) 是一种选择性的 FGFR4 抑制剂，IC₅₀ 值为 75.3 nM。FGFR4-IN-9 有效抑制肝癌细胞的生长和血管生成。

FGFR4-IN-9 Chemical Structure

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生物活性

FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC₅₀ of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC^[1].

IC₅₀ & Target

FGFR4

75.3 nM (IC₅₀)

分子量

522.90

Formula

C₂₄H₂₂ClF₃N₄O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Chaudhary CL, et al. 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation. J Enzyme Inhib Med Chem. 2022 Dec;37(1):844-856.

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