FLT3/ITD-IN-4

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FLT3/ITD-IN-4 

FLT3/ITD-IN-4 (Compound 16) 是一种选择性的 FLT3 内部串联重复突变 (FLT3-ITD) 抑制剂，IC50 值为 2.3 nM。FLT3/ITD-IN-4 可用于急性骨髓性白血病的研究。

FLT3/ITD-IN-4

FLT3/ITD-IN-4 Chemical Structure

CAS No. : 2278278-04-7

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生物活性

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

IC50 & Target

CDK16/Cyclin Y

1768 nM (EC50)

MAP4K4

5737 nM (EC50)

FLT3-ITD

2.3 nM (IC50)

FLT3 D835Y

4.84 nM (IC50)

RET

277 nM (EC50)

FLT3

443 nM (EC50)

ZAK/MLTK

1069 nM (EC50)

DDR2

2494 nM (EC50)

EPHA7

3255 nM (EC50)

NTRK1

3857 nM (EC50)

分子量

458.47

Formula

C25H22N4O5
CAS 号

2278278-04-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232.

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