BRAF V600E/CRAF-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BRAF V600E/CRAF-IN-2 

BRAF V600E/CRAF-IN-2 (Compound 9c) 是一种有效的 BRAF V600E/CRAF 抑制剂，具有 IC 50s 分别为 0.888 和 0.229 μM。BRAF V600E/CRAF-IN-2 在 HCT-116 结肠癌细胞的 G0/G1 期触发细胞凋亡和细胞周期停滞。BRAF V600E/CRAF-IN-2具有研究癌症疾病的潜力。

BRAF V600E/CRAF-IN-2

BRAF V600E/CRAF-IN-2 Chemical Structure

CAS No. : 2499499-62-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

分子量

549.59

Formula

C30H30F3N5O2
CAS 号

2499499-62-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务