上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
GLS1 Inhibitor-4
GLS1 Inhibitor-4 (compound 41e) 是一种有效的 GLS1 抑制剂,IC50 为 11.86 nM。GLS1 Inhibitor-4 显示出抗增殖活性、良好的代谢稳定性和强大的 GLS1 结合亲和力。GLS1 Inhibitor-4 阻断谷氨酰胺代谢并诱导 ROS 的产生。GLS1 Inhibitor-4 可诱导细胞凋亡 (apoptosis)并显示出抗肿瘤活性。
GLS1 Inhibitor-4 Chemical Structure
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100 mg | 询价 | ||
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生物活性 |
GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity[1]. |
IC50 & Target |
IC50: 11.86 nM (GLS1)[1] |
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体外研究 (In Vitro) |
GLS1 Inhibitor-4 (compound 41e) shows antiproliferative activity with IC50s of 0.051, 0.37, 0.32, 1.34 µM for HCT116 and MDA-MB-436, CT26, H22 cells, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[1]
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体内研究 (In Vivo) |
GLS1 Inhibitor-4 (50, 100 mg/kg; i.p.; twice a day for 21 consecutive days) shows antitumor activity in a dose-dependent manne[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
668.72 |
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Formula |
C29H27F3N10O2S2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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