CAIX/CAXII-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CAIX/CAXII-IN-1 

化合物9对肿瘤特异性CA IX/CA XII（KI=29.1和8.8 nM）最有效，因此有可能在体外评估其对HepG-2、HCT-116和MCF-7癌细胞系的细胞毒性和选择性，而其对肿瘤细胞的IC50值分别为1.78、1.94和3.07μM，表明其有明显的细胞毒性。

CAIX/CAXII-IN-1

CAIX/CAXII-IN-1 Chemical Structure

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生物活性

Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.

分子量

620.48

Formula

C24H21IN4O4S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Soliman AM,et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. Eur J Med Chem. 2020 Aug 15;200:112449.

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