BRAF V600E/CRAF-IN-1

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BRAF V600E/CRAF-IN-1 

BRAF V600E/CRAF-IN-1 (Compound 8b) 是一种有效的 BRAF V600E/CRAF 抑制剂。BRAF V600E/CRAF-IN-1 在 HCT-116 结肠癌细胞的 G0/G1 期触发细胞凋亡和细胞周期停滞。BRAF V600E/CRAF-IN-1具有研究癌症疾病的潜力。

BRAF V600E/CRAF-IN-1

BRAF V600E/CRAF-IN-1 Chemical Structure

CAS No. : 2499499-56-6

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生物活性

BRAF V600E/CRAF-IN-1 (Compound 8b) is a potent inhibitor of BRAF V600E/CRAF. BRAF V600E/CRAF-IN-1 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-1 has the potential for the research of cancer diseases[1].

分子量

505.41

Formula

C25H17F6N3O2

CAS 号

2499499-56-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. El-Damasy AK, et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

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