Antitumor agent-54

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-54 

Antitumor agent-54 (Compound C11) 是一种 14-3-3η 蛋白抑制剂，KD 值为 35 µM。Antitumor agent-54 对几种典型的人肝癌细胞系具有抑制活性。Antitumor agent-54 诱导细胞凋亡 (apoptosis) 和 G1-S细胞周期阻滞，具有良好的代谢稳定性。

Antitumor agent-54

Antitumor agent-54 Chemical Structure

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生物活性

Antitumor agent-54 (Compound C11) is a 14-3-3η protein inhibitor with a KD of 35 µM. Antitumor agent-54 shows inhibitory activities against several typical human liver cancer cell lines. Antitumor agent-54 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability[1].

IC50 & Target

KD: 35 µM (14-3-3η)[1]
分子量

456.58

Formula

C29H32N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gao Z, et al. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. Eur J Med Chem. 2022 Apr 29;238:114402.

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