Obtusifoliol

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Obtusifoliol 

Obtusifoliol 是一种特异的 CYP51 抑制剂，Obtusifoliol 对布鲁氏锥虫 (TB) 和人 CYP51 的亲和力的 Kd 值分别为 1.2 µM 和 1.4 µM。

Obtusifoliol Obtusifoliol

Obtusifoliol Chemical Structure

CAS No. : 16910-32-0

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生物活性

Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].

体外研究
(In Vitro)

Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7; MDA-MB231 breast cancer cells
Concentration: 0.1, 1, 10, 40, 80, and 100 µM
Incubation Time: 48 hours
Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.

分子量

426.72

Formula

C30H50O
CAS 号

16910-32-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99.

    [2]. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.

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